Inside Jim Gaffigan’s incredible 50 lbs. weight loss transformation as star turns 60

Speaking with People, Jim explained his initial hesitance about going the route of a GLP-1. “I had very low expectations because I did know someone that had tried it and they were like, ‘Oh no, I was just nauseous for a week.’ And then I thought my true joy of eating would overpower anything.”

He noted that he’d dealt with fluctuations in his weight ever since he was in his 20s, and growing older especially impacted his ability to work the pounds off. “[I] would work out twice a day just to be thin so I could eat,” he told People. “And then as my metabolism slowed down, it became harder and harder, and then my knees started giving out, and then fatigue set in.”

In his 2024 special, the Unfrosted star joked about being confronted by people for being on Ozempic, then the most well-known weight loss drug. “People will come up to me and accuse me of being on an appetite suppressant.”

“They’re like, ‘You’re on Ozempic. Admit it, you’re on Ozempic.’ And I’m not, alright? I’m on a different one,” he quipped. “I’m on Mounjaro, which is better, right? Because it sounds like an Italian restaurant.”

During an appearance on TODAY’s Fourth Hour in 2025, Jim noted that he definitely did see the health benefits pretty quickly. “It’s always good, you know, like, ‘The health benefit, I’ll live longer,’ blah, blah, blah, but I love it just because I feel better,” he quipped. “It is great. It’s beneficial.”

Speaking with TODAY anchor Craig Melvin on his podcast Glass Half Full in March 2026, Jim confirmed that he’s still actively using Mounjaro. “It’s weird. It’s just something that’s in the background of my life at this point where I will take it definitely because I’m still paranoid that I’m going to feel nauseous.”

In a conversation with Men’s Health, he shared: “People used to always say, ‘If you lost weight, you’d lose your whole act.’ It’s so strange, because in some ways, we’re not the funny big guy, are we? That’s the role that I’m supposed to play. But also in some ways, that may be the avenue of our warmth.”