Joe Manganiello reveals life-threatening health battle resulting in ‘amputation’

Joe Manganiello revealed he suffered from life-threatening autoimmune-related illnesses that resulted in him having an amputation.

In the synopsis of the “Spider-Man” actor’s forthcoming memoir, “Bloodlines,” he said he dealt with “a cascade of autoimmune-related illnesses” that attacked his thyroid, digestive system, skin, lungs and eyes.

During the seven-year battle, Manganiello, 49, dealt with “chronic pain, a life-saving organ amputation, existential crisis and a prolonged fight for survival that left doctors with few answers and no clear explanation.”

When doctors were unable to explain what was happening to the “Magic Mike” star, he turned to an unorthodox form of treatment.

Manganiello used “shamans, pagan rituals, ancient myths, long-lost family records and the rebirth of his own spirituality” to try to aid his illness.

The actor also did a deep dive into his own family genealogy and discovered ancestors who survived the Armenian genocide and others who lived with chronic illness.

“It was the most brutally difficult time of my life, one I wouldn’t wish on my worst enemy, but also my greatest adventure,” Manganiello told People in a statement.

“I hope that what I went through on this journey can give readers hope that answers and healing may lie for them on the other side of whatever they are fighting through,” he added.

“The process of writing this book gave me the gift of perspective that helped me to see that my suffering was a cocoon from which I would emerge forever changed.”

It’s unclear when the “True Blood” alum dealt with the illness.

Manganiello was married to Sofía Vergara from 2015 to 2024. The actor and the “Griselda” star, 53, split because she did not want to have any more kids.

Manganiello popped the question to Catlin O’Connor in June 2025.

“Bloodlines” is set to be released on Oct. 13.