Stars who’ve used weight-loss drugs

Ozempic is the newest craze to take over Hollywood.

While stars like Kyle Richards have denied using the Type II diabetes medication — which is injected once a week into the stomach, thigh or arm — others have been vocal with their decision to use the drug, or ones similar, to shed weight quickly.

From Elon Musk to Chelsea Handler, find out which celebrities have spoken up about taking Ozempic for weight loss.

Amanda Bynes

Amanda Bynes revealed in December 2025 that she had lost 28 pounds on Ozempic.

“I was 180lbs,” the former actress wrote atop a paparazzi picture of herself, noting that she was “down to 152lbs.”

Bynes added, “I know I still look big but this photo is really inspiring to me!”

The former child star — who “abused Adderall” for years to maintain a certain weight at the height of her fame — told her Instagram followers in March 2024 that she had “gained over 20lbs in the past few months from being depressed.”

Vanessa Williams

In January 2026, Vanessa Williams told Hello! magazine she’s been combating menopausal weight gain with Mounjaro for the past two years.

“It’s a game‑changer,” the 62-year-old actress shared. “When I turned 60, I was like: ‘I want to be here for a long time, and I want to look my best. So what am I going to do?’”

Andy Cohen

Andy Cohen candidly revealed he lost “a good chunk of weight” after he started “micro-dosing” on a GLP-1 weight loss drug.

“I was really unhappy with my weight. My doctor and I talked about this last year, had recommended a GLP-1 a few times to not only address what I was feeling about my weight, but treat plaque in my arteries and high blood pressure,” Cohen said on the September 9, 2025, episode of his SiriusXM “Andy Cohen Live” radio show.

The star didn’t disclose which GLP-1 medication he was taking but explained that it “is a medication that actually is beneficial to a lot of elements of health and I finally said yes.”

“I have to say, it really helped me with cravings,” he continued, “which I was having a very hard time with, and really forcing myself to be more disciplined with my diet and with working out.”

Serena Williams

Serena Williams admitted to using the GLP-1 medication Ro to lose more than 30 pounds.

“I feel great,” she told People on July 21, 2025. “I feel really good and healthy. I feel light physically and light mentally.”

Williams explained that her struggles with weight began in 2017, after she gave birth to her oldest daughter, Alexis Olympia, via an emergency C-section.

“I never was able to get to the weight I needed to be, no matter what I did, no matter how much I trained,” she told the outlet.

“It was crazy because I’d never been in a place like that in my life where I worked so hard, ate so healthy and could never get down to where I needed to be at,” the athlete shared.

“I had never taken shortcuts in my career and always worked really hard. I know what it takes to be the best. So it was very frustrating to do all the same things and never be able to change that number on the scale or the way my body looked.”

Brooks Nader

Brooks Nader has opened up about her use of weight loss medications on several occasions, sharing on her “Love Thy Nader” reality show, “I typically microdose GLP-1.”

“I’m still working on my self-confidence and just my journey with that every day. It’s different now,” Brooks told Us Weekly after the show aired.

Renee Graziano

Renee Graziano revealed that she has lost more than 50 pounds by taking the weight-loss drug Mounjaro.

“OH BABY 😍 IM DOWN 52lbs … I love sharing my weight-loss journey with y’all because truthfully, I’ve been so hard on myself behind the scenes,” she captioned her post on May 5, 2025, which included side-by-side images of how she looked before losing the weight and now.

In the current snap, the “Mob Wives” alum showed off her curves in a body-hugging, floor-length black dress.

“I’ve battled self-criticism in the past! Ripped myself down to the ground!! I truly was so sick and tired of my life and my inability to lose weight so I thought I’d eat until I felt better THAT NEVER HAPPENED, I felt like I was constantly falling short—of how I ‘should’ look, feel, and keep up with what society tells us is acceptable,” she added.

The former reality TV star said she has been taking a weekly Mounjaro shot for five months in addition to other supplements and weekly sessions with a therapist.

“I haven’t felt the need for a plastic surgery shortcut, although I do believe whatever makes you happy and doesn’t jeopardize your life do it!” she said, adding that she has done “a little Botox and a touch of lip filler.”

“The substantial amount of weight that I have lost really has made me feel and look younger than I have in a long time,” Graziano wrote.

Meghan Trainor

Meghan Trainor opened up about her Mounjaro use while breaking down her dramatic weight loss via Instagram on March 31, 2025.

“Yes, I used science and support (shoutout to Mounjaro!) to help me,” the singer wrote of becoming her “healthiest, strongest” self.

The pop star also credited a dietician, a trainer and “huge lifestyle changes” for her headline-making slimdown.

Fat Joe

Fat Joe spoke about using Ozempic to help shed a whopping 200 pounds in an interview with Us Weekly shared Oct. 14, 2024.

“Ozempic says you may only have two pieces of your favorite stuff,” he told the outlet.

The rapper, whose real name is Joseph Antonio Cartagena, also said that his knowledge over what kind of foods to avoid contributed to the transformation, as well.

“We just try to eat everything with the least carbs as possible. So we try to stay away from the bread, the pasta, the rice. That’s the smartest way to eat,” he told the outlet.

Fat Joe said that he’s also focused in on portion control and learning how to eat in moderation.

“Like this morning I ate breakfast, I had this toast. I cut the corner off, ate it and kept it moving. Normally I would’ve ate [sic] the whole thing. But you know, that’s what we do. We cut carbs and try to be smarter,” he explained.

Kathy Bates

Kathy Bates revealed in an interview that she has lost 20 pounds using Ozempic. Before using the weight loss drug, the actress shed 80 pounds through her diet and lifestyle.

“There’s been a lot of talk that I just was able to do this because of Ozempic,” she told People in October 2024. “But I have to impress upon people out there that this was hard work for me, especially during the pandemic. It’s very hard to say you’ve had enough.”

The “Misery” star went on a weight-loss journey several years ago after being diagnosed with Type 2 diabetes.

The Oscar winner admitted to the magazine that she “used to eat terribly” — “burgers and Cokes and pizza” — for emotional reasons.

“I ate because I was afraid, and I ate because it was a FU to my self-esteem,” she explained. “[Diabetes] runs in my family, and I’d seen what my father had gone through. He had had a leg amputation. One of my sisters is dealing with it very seriously, and it terrified me. It scared me straight.”

Macy Gray

Macy Gray shared that she has been battling stomach pains and constipation since she began taking Ozempic for weight loss.

The “I Try” singer told her “Surreal Life: Villa of Secrets” castmates Kim Zolciak and Johnny Weir that she had been “up all night” due to her discomfort in the July 2024 episode.

“Oh, boy, my stomach hurts. I’ve just been really constipated,” she said. “I took Ozempic. I can’t go to the bathroom, and I was up all night.”

Gray, whose real name is Natalie McIntyre, then explained that she had turned to the trendy medication to “lose weight really fast” before going on tour.

“Quietly, I’m kind of a vain person. I’ve gained a lot of weight over the past couple years, and this is right about the time when everybody starts talking about this Ozempic,” she admitted in a confessional.

“So, I thought, ‘OK, I’m not taking it off the right way. Let me see if I can get one of these Ozempic [prescriptions],’” the Grammy winner added.

“I was actually trying to take it off [the weight] before the show because I didn’t want to be super fat on TV, but here we are.”

Alabama Barker

Alabama Barker has joined the gaggle of celebrities taking weight-loss medication.

The daughter of Travis Barker and his ex-wife, Shanna Moakler, made the admission in a July 2024 selfie-style video that showed her applying her makeup.

“I have, like, this thing where I photograph so ugly, and people are like, ‘Oh, my God — you’re so fat, and you’re so ugly,’” Alabama explained.

“And it’s, like, I see what you guys are seeing, but just, like, meet me in person. I feel like I don’t look like that.”

In the next breath, however, she added, “But I’m on weight-loss medication because I’m tired of being fat and photographing like a damn ogre.”

Alabama did not name the drug she’s on.

Shanna Moakler

Shanna Moakler told People that she used Mounjaro to lose weight after her parents died seven months apart.

“I was in a very, very dark place. I stopped dieting. I stopped exercising. I just ate like s–t,” she said. “I was so devastated, and I missed my f–king mom and dad. I was like, ‘I’m going to f–king eat the pain away.’”

The former beauty pageant queen didn’t reveal how much weight she’s lost using the drug.

 Braunwyn Windham-Burke

“RHOC” alum Braunwyn Windham-Burke revealed in June 2024 that she began taking Ozempic after she moved to Nashville with her partner, Jennifer Spinner.

“The food is different [in Nashville],” she told Us Weekly. “There’s Loveless Cafe and biscuits and fried chicken… I’m not a person with a lot of self-control.”

The reality star said she gained 20 pounds before turning to the medication to help her slim her waistline.

Kelly Clarkson

Kelly Clarkson revealed in May 2024 that she dropped 60 pounds with the help of a weight-loss drug.

“Mine is a different one than people assume, but I ended up having [use medication], too, because my blood work got so bad,” she told guest Whoopi Goldberg on an episode of ‘The Kelly Clarkson Show.”

Clarkson didn’t reveal the exact pharmaceutical she used, but did confirm it’s not Ozempic.

“Everybody thinks it’s Ozempic — it’s not — it’s something else, but it’s something that aids in helping break down the sugar. Obviously, my body doesn’t do it right.”

Tori Spelling

Tori Spelling revealed she used Ozempic and Mounjaro to lose weight after welcoming her sixth child with Dean McDermott.

“I did Mounjaro and everyone admits it now,” she said during her “Misspelling” podcast on April 16.

The “Beverly Hills, 90210” alum added, “I tried Ozempic and it didn’t work for me.”

Spelling explained she was at 160 pounds when she tried the weight loss medication to slim back down to 120 pounds.

She leaned off Mounjaro in January 2024 after reaching her goal weight.

Rebel Wilson

Rebel Wilson said she briefly used Ozempic to help with her weight loss after shedding 80 pounds.

“Someone like me could have a bottomless appetite for sweets, so I think those drugs can be good,” the “Pitch Perfect” star said during a March 2024 interview with the Sunday Times.

The actress added she no longer uses the diabetes medication.

Tracy Morgan

During an August 2023 “Today” show appearance, Tracy Morgan told Hoda Kotb and Jenna Bush Hager that he takes Ozempic injections every Thursday.

“I ain’t letting it go,” the stand-up comedian said of the diabetes drug. “It cuts my appetite in half. Now I only eat half a bag of Doritos.”

As for his gym routine, the actor added, “I get up at seven every morning, and I’m in the gym at 10. Then I go back to sleep. And that’s my life.”

Michael Rubin

Fanatics founder Michael Rubin revealed in July 2023 that he used Ozempic competitor Mounjaro to shed some unwanted pounds, otherwise he’d “be the Pillsbury Doughboy.”

He then joked that “plastic surgery” would be his “next” step toward eternal youth.

Emily Simpson

“Real Housewives of Orange County” star Emily Simpson said on “Jeff Lewis Live” in June 2023 that she used Ozempic to kickstart her weight loss before going for liposuction and a breast reduction.

“I didn’t like the way it made me feel lethargic and it made me just not have a lot of energy, which was hard with three little kids,” she explained, “but it does make you feel full and it does make you, for me, it was like a refresh.”

Amy Schumer

Amy Schumer said she tried Ozempic and got “so skinny,” but had to stop taking it because the drug made her feel “so sick.”

“[I] couldn’t play with my son,” the comedian said on “Watch What Happens Live” in June 2023. “I was so skinny and he’s throwing a ball at me and [I couldn’t].”

She also slammed celebrities who lie about using the weight-loss drug:

“Everyone has been lying saying, ‘Oh smaller portions.’ Like, shut the f—k up.”

Schumer added, “You are on Ozempic or one of those things or you got work done. Just stop. Be real with the people. When I got lipo, I said I got lipo.”

Gracie McGraw

After posting bikini snaps in June 2023, Gracie McGraw poked fun at accusations that she uses Ozempic as she has been “open” about taking the Type II diabetes drug since being diagnosed with polycystic ovary syndrome.

“I did use Ozempic last year, yes,” Tim McGraw and Faith Hill’s eldest daughter wrote via Instagram. “I am now on a low dose of Mounjaro for my PCOS as well as working out.”

Gracie first shared her PCOS struggles in March 2022.

Lauren Manzo

Caroline Manzo’s daughter, Lauren Manzo, admitted she used the weight-loss drug Mounjaro, a competitor of Ozempic, to lose 30 pounds following a 50-pound weight loss.

“You guys have seen me struggle with [my weight] since I’m 20 years old, and it’s been really hard for me,” she said during Page Six’s “Virtual Reali-Tea” live podcast event in May 2023. “I’ve lost a lot of weight from being on that whole ‘Ozempic’ thing.”

Sharon Osbourne

Sharon Osbourne revealed on “The Talk” that she got “very sick” after using injectable weight-loss drugs for several months.

“The first couple of months, I just felt nauseous. Every day I felt nauseous, my stomach was upset, whatever,” she said.

The former reality star did not specify which medication she used but said it caused her to lose 30 pounds in four months.

Dolores Catania

Dolores Cantina said she used Ozempic to slim down in time for the “Real Housewives of New Jersey” Season 13 reunion taping.

“I wasn’t going to come to the reunion looking any bigger than anyone else, so I got on the bandwagon,” she told Andy Cohen on “Watch What Happens Live” on April 4, 2023.

When the host asked about the side effects, Catania replied, “Just not hungry.”

Jennifer Fessler

“RHONJ” newbie Jennifer Fessler all but confirmed she used a variation of Ozempic to help her drop some pounds.

“I did lose a lot of weight. I took peptides, and I don’t know if you’ve heard of medications associated with [peptides] that help people lose weight,” she said on “WWHL” on March 21, 2023.

Cohen then flat-out asked Fessler whether she was on Ozempic, to which she coyly replied, “You said it, I didn’t. But … whatever works, here I am.”

Golnesa “GG” Gharachedaghi

Golnesa “GG” Gharachedaghi revealed she lost more than 10 pounds on the drug — and even taught her fans how to inject themselves.

“I am on the weight-loss shots, honey, OK,” the “Shahs of Sunset” alum said in an Instagram video on Feb. 28, 2023. “I’m just not going to lie about it because I always keep it real about what is fake.”

Gharachedaghi explained that she experienced health issues in 2022 that made her gain some weight, which she had a “very, very, very hard time getting rid of.”

After showing her Instagram followers how to do their own injections, the former Bravolebrity shaded celebs who denied using Ozempic or any of its alternatives.

“We know who you are,” she said. “We see how skinny y’all are getting. It’s not rocket science. Just saying.”

Chelsea Handler

Chelsea Handler claimed she didn’t know she used to be on Ozempic until a friend, who was also on the weight-loss drug, told her.

“I came back from a vacation, and I injected myself with it. I went to lunch with a girlfriend a few days later, and she was like, ‘I’m not really eating anything. I’m so nauseous. I’m on Ozempic,’” she recalled on the “Call Her Daddy” podcast on Jan. 25, 2023.

“I was like, ‘I’m kind of nauseous, too.’ But I had just come back from Spain and was jet-lagged. I had been there for a month. White privilege.”

After Handler told her friend that she was “on semaglutide,” her pal confirmed that was the generic version of Ozempic.

The comedian later admitted that she was no longer taking the diabetes medication.

“I’m not on it anymore,” she clarified. “I’m an irresponsible drug user, but I’m not gonna take a diabetic drug. I tried it, and I’m not gonna do that. That’s not for me. That’s not right for me.”

Remi Bader

Remi Bader confessed she was on Ozempic before it went viral on TikTok.

The influencer said she was prescribed the drug because she was pre-diabetic and insulin-resistant and gaining weight. However, when she stopped taking it, she “gained double the weight back.”

“I saw a doctor, and they were like, ‘It’s 100 percent because you went on Ozempic,’” she said on the “Not Skinny But Not Fat” podcast on Jan. 12, 2023.

“It was making me think I wasn’t hungry for so long,” the TikTok star added. “I lost some weight. I didn’t want to be obsessed with being on it long-term. I was like, ‘I bet the second I [get] off, I’m going to [be] starving again.’

“I did, and my bingeing got so much worse. So, then I kind of blamed Ozempic.”

Elon Musk

Elon Musk admitted to using Wegovy, an injection used for chronic weight management in adults with obesity and Type II diabetes, high blood pressure or high cholesterol.

When a fan asked “What’s your secret?” and complimented his “ripped” physique, the billionaire tweeted on Oct. 1, 2022, “Fasting” and “Wegovy.”

Oprah Winfrey

After months of speculation, Oprah Winfrey told People in December 2023 that she uses a prescription medication “as a tool to manage” her weight, but did not reveal the exact drug.

“The fact that there’s a medically approved prescription for managing weight and staying healthier, in my lifetime, feels like relief, like redemption, like a gift, and not something to hide behind and once again be ridiculed for,” the talk-show host told the outlet.

She added, “I’m absolutely done with the shaming from other people and particularly myself.”

Sheryl Underwood

Sheryl Underwood joked that she is “almost a baby Kardashian” after losing 100 pounds while taking the weight loss drug Wegovy.

“I’m about three different sizes because I still got a booty. But here’s the bad part — you know how those girls have the hourglass? I’m almost to the hourglass,” she told the Messenger in an interview published in December 2023.

“I’m almost a baby Kardashian. Let me say that. I’m almost a baby Kardashian.”

Due to the drastic weight loss, the “Talk” co-host — who once weighed 250 pounds — revealed she no longer has to take medicine for her previous health issues.

Claudia Oshry

In August 2023, Claudia Oshry got emotional as she revealed to her fans that she had been taking Ozempic for the past year.

“The reason I’m nervous about sharing [how much I’ve lost] is because I’m ashamed of myself that I got to a place where I had 70 pounds to lose,” she said on an episode of “The Toast” at the time.

“I could cry I’m so mad at myself,” she added, breaking down in tears.

The comedian, known for her Instagram handle @girlwithnojob, joked that she never thought she was “that big” because she’s “so delusional.”

“To be a fat woman is one of the hardest things to do in this world. [But] I feel like I handled it as good as I could have and I’m proud of the fact I was able to have a full life [before losing weight],” Oshry said.

Boy George

British musician Boy George admitted to using both Ozempic and its competitor Mounjaro in his autobiography, “Karma.”

“I have struggled with my weight most of my life, and being under public and media scrutiny doesn’t help,” he wrote in the book.

The singer called the weight-loss medication a “wonder drug” and insisted “anyone who was fat last year and is now skinny” is using the prescription.

Heather Gay

“Real Housewives of Salt Lake City” star Heather Gay admitted that she was on the Ozempic train in November 2023.

“I’ve been on it for a long time, but hadn’t really seen much results,” she told People at Variety’s Women in Reality TV event in Los Angeles.

“And I haven’t had massive results, but enough for people to notice, which is great.”

Gay has witnessed, however, that people treat her differently even with just minor weight loss.

“You lose five pounds, people are nicer to you,” the reality star said.

“I don’t know why. It’s just the way the world works and that makes me sad for women. But happy that I’m down five.”